Have you noticed how most storytelling, particularly TV shows (which may be the most important form of storytelling right now), all consists of people trying to break free of something, and they never do.
That's why I enjoy the rare story like Office Space, where they actually succeed.
How about a story about an office girl who decides that she'd rather be a lesbian and a rock basist in Manchester, she goes and it actually works and she's a lot happier!
Sure, there'll be problems along the way to keep the story interesting, but none of that banging-the-head-on-the-wall forever stuff. It's stale and unproductive.